2-(氨基甲基)-4-甲基戊酸合成路线 （共 7 条）
反应条件
1: With hydrazine in methanol T=20°C; 0.5 h; 2: With sulfuric acid in water 16 h; Reflux;
参考文献
PONIARD PHARMACEUTICALS, INC.
Patent: WO2009/139834 A1, 2009 ;
Location in patent: Page/Page column 191-192 ;
反应条件
1: H2 / Raney-Ni / ethanol 2: aq. HCl View Scheme
参考文献
Testa,E. et al.
Justus Liebigs Annalen der Chemie, 1961 , vol. 639, p. 166 - 180
反应条件
lithium hydroxide in water
参考文献
Moumne, Roba; Lavielle, Solange; Karoyan, Philippe
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3332 - 3334
反应条件
1: Pd/C; ammonium formate / tetrahydrofuran; methanol / 20 °C 2: LiOH / H2O View Scheme
参考文献
Moumne, Roba; Lavielle, Solange; Karoyan, Philippe
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3332 - 3334
反应条件
1: 70 percent / sodium bromide; sodium nitrite; aq. H2SO4 / H2O / 7 h / 0 - 20 °C 2: 79 percent / sulfuric acid / 1 h / Heating 3: 66 percent / zinc; dibromoethane / various solvent(s) / 1.5 h / 20 °C 4: Pd/C; ammonium formate / tetrahydrofuran; methanol / 20 °C 5: LiOH / H2O View Scheme
参考文献
Moumne, Roba; Lavielle, Solange; Karoyan, Philippe
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3332 - 3334
反应条件
1: 79 percent / sulfuric acid / 1 h / Heating 2: 66 percent / zinc; dibromoethane / various solvent(s) / 1.5 h / 20 °C 3: Pd/C; ammonium formate / tetrahydrofuran; methanol / 20 °C 4: LiOH / H2O View Scheme
参考文献
Moumne, Roba; Lavielle, Solange; Karoyan, Philippe
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3332 - 3334
反应条件
1: 66 percent / zinc; dibromoethane / various solvent(s) / 1.5 h / 20 °C 2: Pd/C; ammonium formate / tetrahydrofuran; methanol / 20 °C 3: LiOH / H2O View Scheme
参考文献
Moumne, Roba; Lavielle, Solange; Karoyan, Philippe
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3332 - 3334
