4,5-二甲氧基-2-硝基苯甲酸乙酯合成路线 （共 17 条）
反应条件
sulfuric acid 18 h; Heating;
参考文献
Ogita, Haruhisa; Isobe, Yoshiaki; Takaku, Haruo; Sekine, Rena; Goto, Yuso; Misawa, Satoru; Hayashi, Hideya
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 6 p. 1865 - 1871
参考文献
Chemische Berichte, , vol. 9, p. 939
Chemische Berichte, , vol. 11, p. 131
反应条件
1: hydrogen chloride 2: durch Nitrieren View Scheme
参考文献
Chemische Berichte, , vol. 9, p. 939
Chemische Berichte, , vol. 11, p. 131
反应条件
1: water; KMnO4 / 80 - 90 °C 2: hydrogen chloride 3: durch Nitrieren View Scheme
参考文献
Chemische Berichte, , vol. 9, p. 939
Chemische Berichte, , vol. 11, p. 131
反应条件
sodium hydrogen telluride; acetic acid 0.5 h; Heating; Yield given. Yields of byproduct given;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 24, p. 690
反应条件
1: ethyl 2-nitro-4,5-dimethoxybenzoate With sodium hydroxide; water 48 h; Heating / reflux; 2: With hydrogenchloride; water pH=2; 3: methanol With thionyl chloride 72 h; Heating / reflux;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2009/53694 A1, 2009 ;
Location in patent: Page/Page column 181 ;
WO 2009/053694 A1
反应条件
1: platinum; ethanol / Hydrogenation 2: sodium; ethyl acetate 4: acetic acid anhydride 5: aqueous NH3 View Scheme
参考文献
Fetscher; Bogert
Journal of Organic Chemistry, 1939 , vol. 4, p. 71,80
反应条件
1: 10 palladium on activated charcoal; hydrogen 2: 160 - 170 °C 3: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 4: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 5: trichlorophosphate / toluene / Reflux 6: pyridine / isopropyl alcohol / Reflux View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
1: 10 palladium on activated charcoal; hydrogen 2: 160 - 170 °C View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: hydrogen; palladium on activated charcoal / methanol 2: 165 - 170 °C 3: trichlorophosphate / toluene View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
