(2S)-2-[(4S,7aR)-4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-7A-甲基八氢-1H-茚-1-基]丙基4-甲基苯磺酸酯合成路线 （共 13 条）
反应条件
1: pyridine; 4-(N,N-dimethlyamino)pyridine / 20 °C 2: 2,6-dimethylpyridine / dichloromethane / -40 °C View Scheme
参考文献
Hatakeyama, Susumi; Yoshino, Madoka; Eto, Kohei; Takahashi, Keisuke; Ishihara, Jun; Ono, Yoshiyuki; Saito, Hitoshi; Kubodera, Noboru
Journal of Steroid Biochemistry and Molecular Biology, 2010 , vol. 121, # 1-2 p. 25 - 28
反应条件
1: 1.) ozone, 2.) NaBH4 / 1.) MeOH, pyridine, CH2Cl2, -78 deg C, 1 h, 2.) RT, 12 h 2: 95 percent / pyridine / 2 h / 0 °C View Scheme
参考文献
Mascarenas, J. L.; Mourino, A.; Castedo, L.
Journal of Organic Chemistry, 1986 , vol. 51, # 8 p. 1269 - 1272
反应条件
1: 1.) n-BuLI, 2.) / 1.) dioxane, from 5 deg C to 25 deg C, 1.5 h, 2.) dioxane, reflux, 40 h 2: 99 percent / NaHCO3, H2 / 5percent Rh/C / ethyl acetate / 18 h / 760 Torr 3: 87 percent / AG 50W-X4 / CH2Cl2; methanol / 1 h / Ambient temperature 4: 93 percent / pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature 5: 98 percent / CH2Cl2 / 18 h / Ambient temperature 6: 1.) n-BuLi / 1.) THF, n-hexane, -78 deg C, 5 min, 2.) THF, n-hexane, -78 deg C, 2 h View Scheme
参考文献
Baggiolini, Enrico G.; Iacobelli, Jerome A.; Hennessy, Bernard M.; Batcho, Andrew D.; Sereno, John F.; Uskokovic, Milan R.
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3098 - 3108
