4,5-二氯-3-吡啶羧醛合成路线 （共 2 条）
反应条件
1: 3,4-dichloropyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - -30°C; 3.8 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; GOODACRE, Simon; LAI, Yingjie; LIANG, Yun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/66061 A1, 2012 ;
Location in patent: Page/Page column 122 ;
WO 2012/066061 A1
反应条件
1: 3,4-dichloropyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-70 - -40°C; 2.25 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes T=-40°C; 1 h; 3: With ammonium chloride in tetrahydrofuran; hexanes; water T=-5°C; 0.05 h;
参考文献
GENENTECH, INC.
Patent: WO2008/24725 A1, 2008 ;
Location in patent: Page/Page column 85 ;
WO 2008/024725 A1
