(3-氯苯基)-哌嗪-1-甲酮合成路线 （共 5 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C;
参考文献
ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Cheryl, A.; JONES, Todd, K.; WANG, Dong-Hui; WEBER, Olivia; CRAVATT, Benjamin, F.; NIPHAKIS, Micah, J.; COGNETTA, Armand; CHANG, Jae Won
Patent: WO2013/142307 A1, 2013 ;
Location in patent: Paragraph 00493 ;
反应条件
acetic acid in tetrahydrofuran T=20°C; Acylation; 1 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 6 p. 808 - 816
反应条件
1: SOCl2 / Heating 2: AcOH / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 6 p. 808 - 816
反应条件
hydrogenchloride in dimethyl sulfoxide; acetonitrile T=25°C; Substitution; Kinetics;
参考文献
Journal of Organic Chemistry, , vol. 65, # 18 p. 5659 - 5663
反应条件
in water; dimethyl sulfoxide T=25°C; Kinetics; Time;
参考文献
Bulletin of the Korean Chemical Society, , vol. 32, # 4 p. 1153 - 1157
