4,4'-di-tert-butylbiphenyl; lithium in tetrahydrofuran T=0°C; Wittig rearrangement; 1 h;

1: 1.) (NH4)2SO4, 1,1,1,3,3,3-hexamethyldisilazane, 2.) CsI / 1.) reflux, 15 h, 2.) MeCN, reflux, 2 h 2: 1.) lithium diisopropylamide (LDA) / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209232', constants.ctx, '0')">chloro-trimethyl-silane</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098295', constants.ctx, '0')">tetrachloromethane</a> <br />T=20&deg;C;&nbsp;2.5&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) NaH, NaI / 1.) liq. paraffin, 1,2-dimethoxyethane, 4 deg C, 30 min, 2.) liq. paraffin, 1,2-dimethoxyethane, RT, 6 h<br />2: SO₂Cl₂ / CH₂Cl₂ / 0.5 h / Ambient temperature<br /> <br /> &nbsp;