2-溴-4-硝基苯甲酸甲酯合成路线 （共 17 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=0 - 25°C; 12 h;
参考文献
NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang
Patent: WO2013/148365 A1, 2013 ;
Location in patent: Paragraph 00101 ;
反应条件
thionyl chloride in methanol T=0°C; 6 h; Inert atmosphereReflux;
参考文献
Jung, Kwan-Young; Vanommeslaeghe, Kenno; Lanning, Maryanna E.; Yap, Jeremy L.; Gordon, Caryn; Wilder, Paul T.; Mackerell, Alexander D.; Fletcher, Steven
Organic Letters, 2013 , vol. 15, # 13 p. 3234 - 3237
反应条件
thionyl chloride Esterification; 3 h; Heating;
参考文献
Qian, Yimin; Marugan, Juan Jose; Fossum, Renae D.; Vogt, Andreas; Sebti, Said M.; Hamilton, Andrew D.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 12 p. 3011 - 3024
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=65°C; 1.16667 h;
参考文献
WO2007/138033 A1, ;
Page/Page column 32-33 ;
反应条件
N-bromosuccinmide; trifluorormethanesulfonic acid; palladium diacetate; N-fluoropyridinium trifluoromethanesulfonate in 1,2-dichloro-ethane T=100°C; 6 h; Sealed tube; regioselective reaction;
参考文献
Sun, Xiuyun; Shan, Gang; Sun, Yonghui; Rao, Yu
Angewandte Chemie - International Edition, 2013 , vol. 52, # 16 p. 4440 - 4444
Angew. Chem., 2013 , vol. 125, # 16 p. 4536 - 4540,5
反应条件
1: pyridine; potassium permanganate / water / 12 h / Reflux 2: thionyl chloride / 6 h / Reflux 3: triethylamine / 1 h View Scheme
参考文献
Chinese Chemical Letters, , vol. 22, # 12 p. 1411 - 1414
参考文献
Organic Letters, , vol. 7, # 12 p. 2417 - 2420
参考文献
Chinese Chemical Letters, , vol. 22, # 12 p. 1411 - 1414
反应条件
1: 73 percent / Na3PO4; Pd(PPh3)4 / dimethylformamide / 100 °C 2: 98 percent / aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Straniero, Valentina; Pallavicini, Marco; Chiodini, Giuseppe; Ruggeri, Paola; Fumagalli, Laura; Bolchi, Cristiano; Corsini, Alberto; Ferri, Nicola; Ricci, Chiara; Valoti, Ermanno
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 13 p. 2924 - 2927
反应条件
1.1: SnCl2·2H2O / ethyl acetate / 50 °C / |Inert atmosphere 2.1: sulfuric acid / water / 5 h / 90 °C / |Inert atmosphere 2.2: 0 - 20 °C / |Inert atmosphere 2.3: 1 h / 90 °C / |Inert atmosphere View Scheme
参考文献
Jung, Kwan-Young; Vanommeslaeghe, Kenno; Lanning, Maryanna E.; Yap, Jeremy L.; Gordon, Caryn; Wilder, Paul T.; Mackerell, Alexander D.; Fletcher, Steven
Organic Letters, 2013 , vol. 15, # 13 p. 3234 - 3237
