2-溴-4-硝基苯甲酸甲酯合成路线 （共 17 条）
反应条件
1.1: SnCl2·2H2O / ethyl acetate / 50 °C / |Inert atmosphere 2.1: sulfuric acid / water / 5 h / 90 °C / |Inert atmosphere 2.2: 0 - 20 °C / |Inert atmosphere 2.3: 1 h / 90 °C / |Inert atmosphere 3.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / |Inert atmosphere 3.2: 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Jung, Kwan-Young; Vanommeslaeghe, Kenno; Lanning, Maryanna E.; Yap, Jeremy L.; Gordon, Caryn; Wilder, Paul T.; Mackerell, Alexander D.; Fletcher, Steven
Organic Letters, 2013 , vol. 15, # 13 p. 3234 - 3237
反应条件
triethanolamine in chloroform; ethyl acetate
参考文献
University of Pittsburgh
Patent: US2002/193596 A1, 2002 ;
反应条件
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; caesium carbonate / 20 - 130 °C
2: methanol; lithium hydroxide hydrate / water; tetrahydrofuran / |Reflux
View Scheme
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
反应条件
SnCl2·2H2O in ethyl acetate
T=50°C; Inert atmosphere;
参考文献
Jung, Kwan-Young; Vanommeslaeghe, Kenno; Lanning, Maryanna E.; Yap, Jeremy L.; Gordon, Caryn; Wilder, Paul T.; Mackerell, Alexander D.; Fletcher, Steven
Organic Letters, 2013 , vol. 15, # 13 p. 3234 - 3237
反应条件
ammonium chloride in aqueous 2-propanol
参考文献
Liu, Gang; Szczepankiewicz, Bruce G.; Pei, Zhonghua; Xin, Zhili; Oost, Thorsten K.; Janowick, David A.
Patent: US2002/35137 A1, 2002 ;
反应条件
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; caesium carbonate / 20 - 130 °C
2: methanol; lithium hydroxide hydrate / water; tetrahydrofuran / |Reflux
View Scheme
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
反应条件
1: 91 percent / Ph3P / Pd2(dba)3
2: 70 percent / NaOH
3: oxalyl chloride, DMF / benzene / 0.5 h
4: 80 percent / DMAP / CH2Cl2 / Ambient temperature
5: 96 percent / HCl / ethyl acetate / Ambient temperature
6: 88 percent / HBF4, isoamyl nitrite / ethanol / 0.5 h / 0 °C
7: 24 percent / NaI / acetone / 6 h / Ambient temperature
View Scheme
参考文献
Crich, David; Hao, Xiaolin
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5982 - 5987
