4-(苄基氨基)-2-(甲基硫代)嘧啶-5-羧酸乙酯合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 5 h;
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
参考文献
Amgen Inc.
Patent: US2003/225106 A1, 2003 ;
Location in patent: Page 133 ;
反应条件
sodium hydroxide in tetrahydrofuran; methanol
T=50°C; 5 h;
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
参考文献
Pratt, John K.; Betebenner, David A.; Donner, Pamela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong
Patent: US2004/162285 A1, 2004 ;
反应条件
1: 100 percent / NaOH / methanol; tetrahydrofuran / 5 h / 50 °C
2: 98 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; NH4OH / dimethylformamide; H2O / 16 h / 20 °C
View Scheme
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
反应条件
1: 100 percent / NaOH / methanol; tetrahydrofuran / 5 h / 50 °C
2: 98 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; NH4OH / dimethylformamide; H2O / 16 h / 20 °C
3: 91 percent / N-methylpyrrolidinone; m-chloroperbenzoic acid / 3 h
View Scheme
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
