5-[双(甲基硫代)亚甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮合成路线 （共 9 条）
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione With carbon disulfide; triethylamine in dimethyl sulfoxide T=20°C; 1 h; 2: methyl iodide in dimethyl sulfoxide T=0 - 20°C; 15 h;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/56562 A1, 2005 ;
Location in patent: Page/Page column 79 ;
WO 2005/056562 A1
反应条件
carbon disulfide; triethylamine 1) DMSO, 1 h, rt, 2) 14 h; Yield given. Multistep reaction;
参考文献
American Home Products Corporation
Patent: US4547516 A1, 1985 ;
反应条件
in dimethyl sulfoxide 4 h; Ambient temperature; Yield given;
参考文献
KUDOS PHARMACEUTICALS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2006/109081 A1, 2006 ;
Location in patent: Page/Page column 50 ;
反应条件
in dimethyl sulfoxide 5 h; Ambient temperature;
参考文献
Hunter, Gordon A.; McNab, Hamish
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 10 p. 1209 - 1214
反应条件
1: dimethylsulfoxide / 1 h / Ambient temperature 2: dimethylsulfoxide / 4 h / Ambient temperature View Scheme
参考文献
Huang, Xian; Chen, Bang-Chi
Synthesis, 1986 , # 11 p. 967 - 968
反应条件
in tetrahydrofuran 1 h;
参考文献
Hunter, Gordon A.; McNab, Hamish
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 10 p. 1209 - 1214
反应条件
hydrogenchloride THF, 1.) 1 h, room temp.; Yield given. Multistep reaction;
参考文献
Huang, Xiang; Chen, Bang-chi
Synthesis, 1987 , # 5 p. 480 - 481
参考文献
Bernasconi, Claude F.; Brown, Shoshana D.; Ali, Mahammad; Rappoport, Zvi; Yamataka, Hiroshi; Salim, Hatim
Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4795 - 4802
参考文献
Roberton, Alan D.; Jackson, Shaun; Kenche, Vijaya; Yap, Cindy; Parbaharan, Hishani; Thompson, Phil
Patent: US2003/216389 A1, 2003 ;
US 20030216389 A1
