1: With ozone in dichloromethane T=25°C; 0.5 h; 2: With formic acid; dihydrogen peroxide T=70°C; 0.333333 h; 3: With hydrogenchloride; water T=110°C; 24 h;

1: With ozone in dichloromethane T=25°C; 0.5 h; 2: With formic acid; dihydrogen peroxide T=70°C; 0.333333 h; 3: With hydrogenchloride; water T=110°C; 24 h;

1: With ozone in dichloromethane T=25°C; 0.5 h; 2: With formic acid; dihydrogen peroxide T=70°C; 0.333333 h; 3: With hydrogenchloride; water T=110°C; 24 h;

1: With ozone in dichloromethane T=25°C; 0.5 h; 2: With formic acid; dihydrogen peroxide T=70°C; 0.333333 h; 3: With hydrogenchloride; water T=110°C; 24 h;

triethylamine in dichloromethane T=0 - 20°C;

Grubb's 2nd generation catalyst in toluene T=110°C; 4 h;

Grela-Grubbs-Hoveyda catalyst in 1,2-dichloro-ethane T=90°C; 12 h; Inert atmosphere; optical yield given as percent destereoselective reaction;

1.1: sodium hydrogencarbonate / methanol / 2 h / 70 °C / pH 6 / aq. phosphate buffer 2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C 2.2: 0 - 20 °C 3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C 4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; acetonitrile 5.1: triethylsilane; trifluoroacetic anhydride / 2 h / 0 - 20 °C 6.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C View Scheme

1.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 1 h / 0 °C 1.2: 10 h / 25 °C 2.1: water; lithium hydroxide hydrate / tetrahydrofuran / 3 h / 0 °C 2.2: pH 3 3.1: dichloromethane / 2 h / 25 °C 4.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 24 h / 25 °C 5.1: Grubb's 2nd generation catalyst / toluene / 4 h / 110 °C 5.2: 20 °C View Scheme

1.1: water; lithium hydroxide hydrate / tetrahydrofuran / 3 h / 0 °C 1.2: pH 3 2.1: dichloromethane / 2 h / 25 °C 3.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 24 h / 25 °C 4.1: Grubb's 2nd generation catalyst / toluene / 4 h / 110 °C 4.2: 20 °C View Scheme