反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1: 50 percent / acetic acid<br />2: 69 percent / KOH / ethanol; H<sub>2</sub>O / 0.75 h / Heating<br />3: 1.) n-BuLi / 1.) THF, hexane, -23 deg C, 2 h, 2.) THF, hexane, -23 deg C, 3 h<br />4: NH<sub>3</sub> / tetrahydrofuran; hexane / 0.25 h / 5 °C<br /> <br />
参考文献
Ludeman; Boyd; Regan; Gallo; Zon; Ishii Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 716 - 727