4,4'-二氨基二苯甲烷合成路线 （共 194 条）
反应条件
in chlorobenzene
T=0°C; Heating / reflux; Product distribution / selectivity;
参考文献
Bayer MaterialScience AG
Patent: US2007/265465 A1, 2007 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: pyridine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 25 °C / Inert atmosphere
2: potassium carbonate / tetrahydrofuran / 12 h / 50 °C / Inert atmosphere
View Scheme
参考文献
Kimura, Tsutomu; Hosokawa-Muto, Junji; Kamatari, Yuji O.; Kuwata, Kazuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1502 - 1507
反应条件
1: 1.) NaNO2, conc. H2SO4, 2.) KI / 1.) 5 deg C, 30 min, 2.) H2O, 55 deg C, 1 h
2: 81 percent / palladium(II) acetate, triphenylphosphine, copper(I) iodide, triethylamine / toluene / 4 h / 80 - 90 °C
3: 100 percent / anhydrous potassium carbonate / methanol; diethyl ether / 16 h / 25 °C
View Scheme
参考文献
Austin, William B.; Bilow, Norman; Kelleghan, William J.; Lau, Kreisler S. Y.
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2280 - 2286
参考文献
Wagner
Journal of the American Chemical Society, 1934 , vol. 56, p. 1944
参考文献
Kyazimova; Nagieva
Petroleum Chemistry, 1998 , vol. 38, # 3 p. 212 - 214
反应条件
1: diethyl ether / 24 h / 20 °C
2: NaBH3CN; HCl / methanol / 24 h / 20 °C
View Scheme
参考文献
Sanmartin, Carmen; Echeverria, Mikel; Mendivil, Beatriz; Cordeu, Lucia; Cubedo, Elena; Garcia-Foncillas, Jesus; Font, Maria; Palop, Juan Antonio
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 2031 - 2044
参考文献
Li, Kai; Yuan, Chao; Zheng, Shijun; Fang, Qiang
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4245 - 4247
反应条件
2-methylaniline hydrochloride
T=170°C;
参考文献
Vongerichten; Bock
Z.f.Farben- u.Textilchemie, vol. 2, p. 250
Chem. Zentralbl., 1903 , vol. 74, # II p. 441
参考文献
Vongerichten; Bock
Chem. Zentralbl., 1903 , vol. 74, # II p. 441
反应条件
2: chromium acetic acid
3: sulfuric acid
4: diluted hydrochloric acid; bromine
View Scheme
参考文献
Rivier; Farine
Helvetica Chimica Acta, 1929 , vol. 12, p. 868
