反应条件
1: 1-(mercaptomethyl)-cyclopropaneacetic acid With n-butyllithium in tetrahydrofuran T=-12.5°C; 0.666667 h; 2: 2-(3-(S)-(3-(2-(7-chloroquinolinyl)ethenyl)phenyl)-3-methanesulfonyloxypropyl)phenyl-2-propanol in tetrahydrofuran T=-2°C; 3.5 h; 3: N,N-dicyclohexylamine in isopropyl alcohol; acetonitrile T=29°C; 15.5 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; FOX, Martin Edward; BOLLIKONDA, Satyanarayana; MOHANARANGAM, Saravanan; JINNA, Rajender Reddy; KANDIRELLI, Venkata Kiran Kumar
Patent: WO2010/148209 A2, 2010 ;
Location in patent: Page/Page column 21 ;