1: With sodium hexamethyldisilazane in tetrahydrofuran 0.75 h; 2: With methyl iodide in tetrahydrofuran T=20°C; 0.75 h; 3: With sodium hexamethyldisilazane; methyl iodide more than 3 stages;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: EP1171113 B1, 2004 ;
Location in patent: Page 15 ;