N-甲基-N-羟乙基苄胺合成路线 （共 30 条）
反应条件
sodium methylate in n-heptane Heating;
参考文献
Doyle,F.P. et al.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 571 - 576
反应条件
thionyl chloride T=35°C; 16 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2009/10783 A1, 2009 ;
Location in patent: Page/Page column 36; 94 ;
WO 2009/010783 A1
反应条件
potassium hydroxide in tetrahydrofuran T=25°C; 24 h;
参考文献
Kinugawa, Masahiko; Ogasa, Takehiro
Synthetic Communications, 1997 , vol. 27, # 19 p. 3321 - 3331
反应条件
dihydrogen peroxide Oxidation;
参考文献
Ottolina, Gianluca; Bianchi, Silvia; Belloni, Barbara; Carrea, Giacoma; Danieli, Bruno
Tetrahedron Letters, 1999 , vol. 40, # 48 p. 8483 - 8486
反应条件
ammonium formate; palladium on activated charcoal in methanol 0.166667 h; Heating;
参考文献
Ram, Siya; Spicer, Leonard D.
Synthetic Communications, 1987 , vol. 17, # 4 p. 415 - 418
反应条件
sodium methylate; potassium iodide in methanol Electrochemical reactionCooling;
参考文献
Okimoto, Mitsuhiro; Ohashi, Kousuke; Yamamori, Haruki; Nishikawa, Shinnosuke; Hoshi, Masayuki; Yoshida, Takashi
Synthesis, 2012 , vol. 44, # 9 p. 1315 - 1322
反应条件
1: SOCl2 / CHCl3 / 15 h / Ambient temperature 2: 60 percent / aq. NH3 / 72 h / Ambient temperature View Scheme
参考文献
INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PII SUNYER (IDIBAPS); CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS; MORENO, Beatriz; VILLOSLADA, Pablo; MESSEGUER, Joaquin; NAVARRO, Gloria; MESSEGUER, Angel
Patent: WO2011/24078 A1, 2011 ;
反应条件
sodium methylate; potassium iodide in methanol Electrochemical reactionCooling;
参考文献
Okimoto, Mitsuhiro; Ohashi, Kousuke; Yamamori, Haruki; Nishikawa, Shinnosuke; Hoshi, Masayuki; Yoshida, Takashi
Synthesis, 2012 , vol. 44, # 9 p. 1315 - 1322
反应条件
thionyl chloride in chloroform
15 h; Ambient temperature;
参考文献
Kali-Chemie Pharma GmbH
Patent: US5212173 A1, 1993 ;
参考文献
Krapcho,J. et al.
Journal of Medicinal Chemistry, 1963 , vol. 6, p. 544 - 546
