3-(2-甲氧基乙氧基)-5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-吡啶合成路线 (共 2 条)
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=160°C; 0.333333 h;
参考文献
NOVARTIS AG
Patent: WO2009/10488 A1, 2009 ;
Location in patent: Page/Page column 26 ;
WO 2009/010488 A1
反应条件
1: 3-bromo-5-(2-methoxyethoxy)pyridine With n-butyllithium in diethyl ether; hexane T=-80°C; Inert atmosphere; 2: With boric acid trimethyl ester in diethyl ether; hexane T=-80 - 20°C; 12 h; Inert atmosphere; 3: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether; hexane T=20°C; 6 h; Inert atmosphere;
参考文献
Li, Zhiou; Kishi, Norifumi; Hasegawa, Kimiko; Akita, Munetaka; Yoshizawa, Michito
Chemical Communications, 2011 , vol. 47, # 30 p. 8605 - 8607