(2-氯吡啶-3-基)乙腈合成路线 （共 19 条）
反应条件
1.1: dihydrogen peroxide; acetic acid / toluene / Reflux 1.2: Reflux 2.1: sulfuryl dichloride / methanol / 0 - 20 °C 3.1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran / 0 - 20 °C 4.1: sulfuryl dichloride / dichloromethane / 0 - 20 °C 5.1: ethanol / 20 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 22, # 9 p. 1009 - 1012
反应条件
1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran / 0 - 20 °C 2: sulfuryl dichloride / dichloromethane / 0 - 20 °C 3: ethanol / 20 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 22, # 9 p. 1009 - 1012
反应条件
1: sulfuryl dichloride / methanol / 0 - 20 °C 2: sodium tetrahydroborate; calcium chloride / tetrahydrofuran / 0 - 20 °C 3: sulfuryl dichloride / dichloromethane / 0 - 20 °C 4: ethanol / 20 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 22, # 9 p. 1009 - 1012
参考文献
Journal of the American Chemical Society, , vol. 81, p. 740,742
反应条件
1: concentrated aqueous NH3; CuSO4 / 135 °C 2: 225 °C View Scheme
参考文献
Okuda; Robison
Journal of the American Chemical Society, 1959 , vol. 81, p. 740,742
反应条件
ammonium hydroxide; copper(II) sulfate T=135°C;
参考文献
Okuda; Robison
Journal of the American Chemical Society, 1959 , vol. 81, p. 740,742
参考文献
Okuda; Robison
Journal of the American Chemical Society, 1959 , vol. 81, p. 740,742
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
1.2: 5.16 h / 0 - 20 °C
2.1: dihydrogen peroxide; sodium hydroxide / ethanol / 50 °C
3.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 16 h / 110 °C
4.1: hydrogenchloride / water; ethyl acetate / 3 h / 20 °C
View Scheme
参考文献
Hong, Hui; Huang, Long Jiang; Teng, Da Wei
Chinese Chemical Letters, 2011 , vol. 22, # 9 p. 1009 - 1012
反应条件
1: With water; sodium hydroxide
0.583333 h; Reflux;
2: With hydrogenchloride in water
T=0°C; pH=1; 1 h;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 141 ;
