(Z)-4-(氯(羟基亚氨基)甲基)苯甲酸甲酯合成路线 （共 6 条）
反应条件
N-chloro-succinimide in chloroform T=20°C; 4 h;
参考文献
MERCK SHARP and DOHME CORP.; DANG, Qun; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia
Patent: WO2013/43624 A1, 2013 ;
Location in patent: Page/Page column 103 ;
反应条件
trifluoroacetic acid
参考文献
Singh, Sheo B.; Herath, Kithsiri; Kahn, Jennifer Nielsen; Mann, Paul; Abruzzo, George; Motyl, Mary
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3253 - 3256
反应条件
1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; water / 20 °C 2: N-chloro-succinimide / chloroform / 4 h / 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; DANG, Qun; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia
Patent: WO2013/43624 A1, 2013 ;
反应条件
1: diethyl dicarbonate / tetrahydrofuran 2: tetrachloromethane / acetonitrile / |Reflux 3: trifluoroacetic acid View Scheme
参考文献
Singh, Sheo B.; Herath, Kithsiri; Kahn, Jennifer Nielsen; Mann, Paul; Abruzzo, George; Motyl, Mary
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3253 - 3256
反应条件
1: 84.5 percent / Et3N / tetrahydrofuran 2: 97.8 percent / NaOH / ethanol; tetrahydrofuran 3: 94.9 percent / CH2Cl2 View Scheme
参考文献
Tomishima; Ohki; Yamada; Takasugi; Maki; Tawara; Tanaka
Journal of Antibiotics, 1999 , vol. 52, # 7 p. 674 - 676
反应条件
triethylamine in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3253 - 3256
