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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
4'-甲基-2-联苯醇
合成路线
（共 13 条）
533-58-4
2-碘苯酚
+
5720-05-8
4-甲基苯硼酸
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
palladium diacetate; potassium carbonate in N,N-dimethyl-formamide T=20°C; 5 h; Inert atmosphere;
参考文献
Moteki, Shin A.; Toyama, Kazuya; Liu, Zeyu; Ma, Jing; Holmes, Andrea E.; Takacs, James M.
Chemical Communications, 2012 , vol. 48, # 2 p. 263 - 265
29540-83-8
对苄基三氟甲磺酸
+
269409-97-4
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
lithium hydroxide; palladium diacetate in tetrahydrofuran; water T=20°C; Suzuki-Miyaura cross-coupling; 2 h;
参考文献
Ishikawa, Shunpei; Manabe, Kei
Chemical Communications, 2006 , # 24 p. 2589 - 2591
95-56-7
邻溴苯酚
+
5720-05-8
4-甲基苯硼酸
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
potassium phosphate; PdCl2(GLCAphos)2/2GLCAphos T=80°C; Substitution; 16 h;
参考文献
Nishimura, Masato; Ueda, Masato; Miyaura, Norio
Tetrahedron, 2002 , vol. 58, # 29 p. 5779 - 5787
95-56-7
邻溴苯酚
+
29540-83-8
对苄基三氟甲磺酸
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
1: ortho-bromo-phenol With tert.-butyl lithium in diethyl ether; pentane T=-78°C; 0.5 h; 2: With zinc(II) chloride in tetrahydrofuran T=-78 - 20°C; 3: p-trifluoromethanesulfonyloxytoluene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; palladium diacetate in tetrahydrofuran T=45°C; Negishi coupling reaction; 2 h;
参考文献
Shimizu, Haruka; Manabe, Kei
Tetrahedron Letters, 2006 , vol. 47, # 33 p. 5927 - 5931
92495-53-9
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
boron tribromide in dichloromethane T=0 - 25°C;
参考文献
Zhou, Q. Jean; Worm, Karin; Dolle, Roland E.
Journal of Organic Chemistry, 2004 , vol. 69, # 15 p. 5147 - 5149
928642-45-9
+
624-31-7
4-碘甲苯
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=50°C; 26 h; Inert atmosphere;
参考文献
Yang, Ke; Zhang, Jun; Li, Yun; Cheng, Bin; Zhao, Liang; Zhai, Hongbin
Organic Letters, 2013 , vol. 15, # 4 p. 808 - 811
624-31-7
4-碘甲苯
+
1232692-89-5
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tetrabutyl ammonium fluoride; sodium t-butanolate in tetrahydrofuran; water T=60°C; 1 h; Inert atmosphere;
参考文献
Huang, Chunhui; Chernyak, Natalia; Dudnik, Alexander S.; Gevorgyan, Vladimir
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 8 p. 1285 - 1305
35616-01-4
+
4294-57-9
对甲苯基溴化镁
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
1: (4-Methylphenyl)-magnesium bromide With C24H52Cl2O12P4Pd2 in tetrahydrofuran; 1,4-dioxane T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere; 2: toluene-4-sulfonic acid,2-hydroxyphenyl ester in tetrahydrofuran; 1,4-dioxane T=110°C; Kumada-Corriu cross-coupling reaction; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Ackermann, Lutz; Kapdi, Anant R.; Fenner, Sabine; Kornhaab, Christoph; Schulzke, Carola
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2965 - 2971
95-57-8
邻氯苯酚
+
4294-57-9
对甲苯基溴化镁
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
1: (4-Methylphenyl)-magnesium bromide With C24H52Cl2O12P4Pd2 in tetrahydrofuran; 1,4-dioxane T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere; 2: 2-chlorophenol in tetrahydrofuran; 1,4-dioxane T=110°C; Kumada-Corriu cross-coupling reaction; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Ackermann, Lutz; Kapdi, Anant R.; Fenner, Sabine; Kornhaab, Christoph; Schulzke, Carola
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2965 - 2971
29540-83-8
对苄基三氟甲磺酸
→
反应条件
101043-55-4
4'-甲基-2-联苯醇
反应条件
potassium fluoride; tri-cyclo-hexyl-phosphine; palladium diacetate in water; N,N-dimethyl-formamide T=20°C; Suzuki-Miyaura coupling; 5 h; Product distribution; Further Variations:ReagentsSolvents;
参考文献
Ishikawa, Shunpei; Manabe, Kei
Chemistry Letters, 2006 , vol. 35, # 2 p. 164 - 165
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