2,6-二氯吡啶-3,4-二胺合成路线 （共 16 条）
反应条件
hydrogenchloride; water; iron in ethanol T=95°C; 16 h;
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
1: HNO3; H2SO4 / 20 °C 2: H2SO4 / 100 °C 3: 51 percent / Fe / 2 h / Heating 4: aq. NaOH / Heating View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 22, # 12 p. 2133 - 2144
反应条件
1: H2SO4 / 100 °C 2: 51 percent / Fe / 2 h / Heating 3: aq. NaOH / Heating View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 22, # 12 p. 2133 - 2144
反应条件
1: CF3COOH; aq. H2O2 / 6.5 h / Heating 2: HNO3; H2SO4 / 160 °C 3: AcOH; Fe / Heating 4: HNO3; H2SO4 / 20 °C 5: H2SO4 / 100 °C 6: 51 percent / Fe / 2 h / Heating 7: aq. NaOH / Heating View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 22, # 12 p. 2133 - 2144
反应条件
1: HNO3; H2SO4 / 160 °C 2: AcOH; Fe / Heating 3: HNO3; H2SO4 / 20 °C 4: H2SO4 / 100 °C 5: 51 percent / Fe / 2 h / Heating 6: aq. NaOH / Heating View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 22, # 12 p. 2133 - 2144
反应条件
1: AcOH; Fe / Heating 2: HNO3; H2SO4 / 20 °C 3: H2SO4 / 100 °C 4: 51 percent / Fe / 2 h / Heating 5: aq. NaOH / Heating View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 22, # 12 p. 2133 - 2144
反应条件
sodium hydroxide Heating;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 22, # 12 p. 2133 - 2144
反应条件
1: 5 h / 145 °C 2: formic acid / 5 h / 110 °C 3: toluene-4-sulfonic acid / 0.17 h / 160 °C 4: ammonia / water / 120 h / 200 °C View Scheme
参考文献
Bande, Omprakash; Herdewijn, Piet
European Journal of Organic Chemistry, 2014 , vol. 2014, # 1 p. 231 - 236
反应条件
aq NaOH; oxalic acid in hydrogenchloride
参考文献
State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.
Patent: US5620978 A1, 1997 ;
US 5620978 A
反应条件
acetic anhydride 4.5 h; Heating;
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
