1: With hydrogenchloride; tin(ll) chloride in ethanol; water 1.5 h; Reflux; 2: With sodium hydroxide in ethanol; water

1: (i) aq. KOH, EtOH, (ii) /BRN= 124500/ 2: dimethylformamide / Heating View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: Neat (no solvent); Microwave irradiation<br />2: sodium hydroxide / water<br />3: nitric acid / 40 - 50 &deg;C<br /> <br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '171382', constants.ctx, '0')">EtI</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />0.666667&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '635994', constants.ctx, '0')">dimethyl sulfate</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=0&deg;C;&nbsp;3&nbsp;h;&nbsp;<br /> <br /> &nbsp;