1-(喹啉-2-基)乙酮合成路线 （共 46 条）
反应条件
sulfur; diethylamine T=150°C; Erhitzen des Reaktionsprodukts mit wss. NaOH;
参考文献
CIBA
Patent: DE748539 , 1941 ;
DRP/DRBP Org.Chem.
参考文献
Helvetica Chimica Acta, , vol. 4, p. 807
反应条件
1: 60 percent / m-CPBA 2: 56 percent / POCl3 / CHCl3 / Heating 3: 86 percent / NaN3 / dimethylsulfoxide / Heating View Scheme
参考文献
Sashida; Kaname; Tsuchiya
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 11 p. 2919 - 2925
反应条件
(NH4)2S2O8; sulfuric acid; silver nitrate in dichloromethane; water
T=50°C; 4 h;
参考文献
UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin
Patent: WO2012/168733 A1, 2012 ;
Location in patent: Page/Page column 89-90 ;
WO 2012/168733 A1
反应条件
1: With methyllithium in tetrahydrofuran; diethyl ether
T=0°C; 2 h;
2: With chloro-trimethyl-silane in tetrahydrofuran; diethyl ether
0.166667 h;
3: With hydrogenchloride; sodium hydrogencarbonate
more than 3 stages;
参考文献
PROSIDION LIMITED
Patent: WO2006/85118 A2, 2006 ;
Location in patent: Page/Page column 20-21 ;
WO 2006/085118 A2
反应条件
sodium hydroxide; carbon monoxide; N-hexadecyl-N,N,N-trimethylammonium bromide in water; benzene
T=20°C; P=760 Torr; 20 h;
参考文献
Miura, Masahiro; Akase, Fumiaki; Shinohara, Masato; Nomura, Masakatsu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1021 - 1026
反应条件
hydrogenchloride in 1,4-dioxane; water
T=100°C; 16 h;
参考文献
Largy, Eric; Hamon, Florian; Rosu, Frederic; Gabelica, Valerie; De Pauw, Edwin; Guedin, Aurore; Mergny, Jean-Louis; Teulade-Fichou, Marie-Paule
Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13274 - 13283
反应条件
oxygen; carbon in xylene
T=120°C; 12 h;
参考文献
Sano, Yuki; Tanaka, Takanori; Hayashi, Masahiko
Chemistry Letters, 2007 , vol. 36, # 12 p. 1414 - 1415
反应条件
1: methyl iodide With magnesium
Inert atmosphere;
2: 2-quinolinecarbonitrile in diethyl ether
T=0 - 20°C; Inert atmosphere;
3: With sulfuric acid; water in diethyl ether
T=0 - 20°C; Inert atmosphere;
参考文献
Tan, Qitao; Hayashi, Masahiko
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 16 p. 2639 - 2644
反应条件
1: With 1,3-bis-(diphenylphosphino)propane; thallous acetate; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide
T=80°C; Heck reaction; 24 h;
2: With hydrogenchloride in N,N-dimethyl-formamide
T=20°C; 24 h;
参考文献
Legros, Jean-Yves; Primault, Gaelle; Fiaud, Jean-Claude
Tetrahedron, 2001 , vol. 57, # 13 p. 2507 - 2514
