1-(喹啉-2-基)乙酮合成路线 （共 46 条）
反应条件
1: With triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in toluene
T=110°C; Stille coupling reaction; 12 h;
2: With hydrogenchloride in toluene
T=20°C; 24 h;
参考文献
Legros, Jean-Yves; Primault, Gaelle; Fiaud, Jean-Claude
Tetrahedron, 2001 , vol. 57, # 13 p. 2507 - 2514
反应条件
in tetrahydrofuran; toluene
T=0°C; 2 h;
参考文献
PROSIDION LIMITED
Patent: WO2006/85118 A2, 2006 ;
Location in patent: Page/Page column 20 ;
WO 2006/085118 A2
反应条件
1: With triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=70°C; Negishi coupling reaction; 48 h;
2: With hydrogenchloride in tetrahydrofuran
T=20°C; 24 h;
参考文献
Legros, Jean-Yves; Primault, Gaelle; Fiaud, Jean-Claude
Tetrahedron, 2001 , vol. 57, # 13 p. 2507 - 2514
反应条件
1: With triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=70°C; Negishi coupling reaction; 48 h;
2: With hydrogenchloride in tetrahydrofuran
T=20°C; 24 h;
参考文献
Legros, Jean-Yves; Primault, Gaelle; Fiaud, Jean-Claude
Tetrahedron, 2001 , vol. 57, # 13 p. 2507 - 2514
反应条件
sodium hydroxide; dicobalt octacarbonyl; N-hexadecyl-N,N,N-trimethylammonium bromide in benzene
T=20°C; 20 h;
参考文献
Miura, Masahiro; Akase, Fumiaki; Nomura, Masakatsu
Journal of the Chemical Society, Chemical Communications, 1986 , # 3 p. 241 - 242
反应条件
sulfuric acid; water; mercuric sulphate in acetone
2 h; Heating;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Shiraiwa, Masafumi; Yamanaka, Hiroshi
Synthesis, 1984 , # 3 p. 245 - 247
反应条件
in hexane; dichloromethane
T=-78 - -20°C; 12.5 h;
参考文献
Malkov, Andrei V.; Westwater, Mary-Margaret; Gutnov, Andrey; Ramirez-Lopez, Pedro; Friscourt, Frederic; Kadlcikova, Aneta; Hodacova, Jana; Rankovic, Zoran; Kotora, Martin; Kocovsky, Pavel
Tetrahedron, 2008 , vol. 64, # 49 p. 11335 - 11348
反应条件
NH4S2O8; silver nitrate; trifluoroacetic acid in dichloromethane; water
T=40°C; 2.5 h; Yield given. Yields of byproduct given;
参考文献
Fontana, Francesca; Minisci, Francesco; Barbosa, Maria Claudia Nogueira; Vismara, Elena
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2866 - 2869
反应条件
in benzene
1.) 0 deg C, 1.5 h 2.) room temp., 3 h;
参考文献
Yamamoto, Yutaka; Yanagi, Akihiko
Heterocycles, 1982 , vol. 19, # 1 p. 41 - 44
反应条件
1.1: Pd(dba)2; PPh3 / toluene / 110 °C
1.2: 44 percent / 1N HCl / toluene / 12 h / 20 °C
2.1: HCO2H; Et3N / Pd(OAc)2/dppf / dimethylformamide / 80 °C
View Scheme
参考文献
Legros, Jean-Yves; Primault, Gaelle; Fiaud, Jean-Claude
Tetrahedron, 2001 , vol. 57, # 13 p. 2507 - 2514
