potassium hydroxide in water T=80°C; 3 h;

1: KOH / H2O / 3 h / 80 °C 2: 65 percent / Ac2O / 130 °C View Scheme

1: 92 percent / α-chymotrypsin, aq. KCl / 120 h / Ambient temperature; pH 7.8 2: LiBH4 / 1,2-dimethoxy-ethane; methanol / 1 h / Heating 3: p-toluenesulfonic acid / toluene / 3.5 h / Heating View Scheme