N-2-(溴苯基)甲酰胺合成路线 （共 38 条）
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux 2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: 2.9 g / dimethylformamide / 1 h / Heating 2: 1.) di-t-butyl peroxide, 2.) hydrolysis / 1) chlorobenzene, 110 deg C, 48 h View Scheme
参考文献
Leardini, Rino; Tundo, Antonio; Zanardi, Giuseppe
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3164 - 3167
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux 2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: KOH / dimethylsulfoxide / 4 h / Ambient temperature 2: 77 percent / H2SO4 / H2O / 2 h / Heating View Scheme
参考文献
Heinicke, J.; Nietzschmann, E.; Tzschach, A.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 3 p. 511 - 516
反应条件
2: 80 percent / polyphosphoric acid / 20 h / 160 °C View Scheme
参考文献
Curran, Dennis P.; Kuo, Shen-Chun
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2063 - 2065
反应条件
1.1: i-Pr2NEt; xantphos / Pd2(dba)3 / dioxane / 12 h / Heating 2.1: NaOEt / tetrahydrofuran; ethanol / 1 h / 50 °C 2.2: trifluoroacetic acid / tetrahydrofuran; ethanol / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 18 p. 3687 - 3689
反应条件
1: D2O, KOH 2: 1.) n-butyl-lithium / 1.) hexane, THF, 4 h, -78 deg C; 2.) THF, 2 h, -78 deg C 3: 89 percent / 1.2M aq. potassium hydroxide / methanol / 1.5 h / Heating View Scheme
参考文献
Fleming, Ian; Loreto, Maria Antonietta; Wallace, Ian H.M.; Michael, Joseph P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 349 - 360
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux 2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux 2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: D2O, KOH 2: 1.) n-butyl-lithium / 1.) hexane, THF, 4 h, -78 deg C; 2.) THF, 2 h, -78 deg C 3: 89 percent / 1.2M aq. potassium hydroxide / methanol / 1.5 h / Heating 4: 68 percent / 98percent H2SO4 / 0.75 h / 5 °C View Scheme
参考文献
Fleming, Ian; Loreto, Maria Antonietta; Wallace, Ian H.M.; Michael, Joseph P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 349 - 360
