N-2-(溴苯基)甲酰胺合成路线 （共 38 条）
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / toluene / 16 h / 110 °C / Inert atmosphere 2: diisopropylamine; trichlorophosphate / chloroform / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Mitamura, Takenori; Iwata, Kimiyo; Ogawa, Akiya
Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 3880 - 3887
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux 2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube View Scheme
参考文献
Journal of the American Chemical Society, , vol. 136, # 3 p. 1125 - 1131
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride T=100°C; 5 h;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 35, # 5 p. 1823 - 1828
反应条件
1: n-butyl lithium / hexane; tetrahydrofuran / -100 °C
2: 56 percent / tetrahydrofuran / -105 °C
3: 88 percent / dimethylformamide / 80 °C
4: HCl / H2O / 144 h / 165 °C
View Scheme
参考文献
Fleming, Ian; Loreto, Maria Antonietta; Wallace, Ian H.M.; Michael, Joseph P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 349 - 360
反应条件
1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h
2.2: 0.5 h
3.1: tri-ruthenium(0)dodecacarbonyl; tetra-(n-butyl)ammonium iodide / toluene; dimethyl sulfoxide / 12.08 h / 20 - 120 °C / |Sealed tube
View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux
2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube
View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: KOH / dimethylsulfoxide / 4 h / Ambient temperature
2: 77 percent / H2SO4 / H2O / 2 h / Heating
3: 1.) n-BuLi / 1.) ether/hexane; 2.) ether, 20 deg C, 15 h
View Scheme
参考文献
Heinicke, J.; Nietzschmann, E.; Tzschach, A.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 3 p. 511 - 516
反应条件
1: KOH / dimethylsulfoxide / 4 h / Ambient temperature
2: 77 percent / H2SO4 / H2O / 2 h / Heating
3: 51 percent / TEA / diethyl ether / 5 h, reflux; 2 d, 20 deg C
View Scheme
参考文献
Heinicke, J.; Nietzschmann, E.; Tzschach, A.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 3 p. 511 - 516
反应条件
2: 1N HCl / dioxane / 18 h
View Scheme
参考文献
Curran, Dennis P.; Kuo, Shen-Chun
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2063 - 2065
反应条件
2: TiCl4 / CH2Cl2 / 1.5 h / -78 °C
View Scheme
参考文献
Curran, Dennis P.; Kuo, Shen-Chun
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2063 - 2065
