(L)-2-二氮杂乙酰基吡咯烷-1-羧酸叔丁酯合成路线 （共 15 条）
反应条件
1: 1-(tert-butoxycarbonyl)-L-proline With pyridine; 4-(N,N-dimethlyamino)pyridine; di-tert-butyl dicarbonate in tetrahydrofuran T=0°C; 2: diazomethane in tetrahydrofuran; diethyl ether T=0°C; 0.5 h;
参考文献
Vasanthakumar, Ganga-Ramu; Patil, Basanagoud S.; Suresh Babu, Vommina V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 18 p. 2087 - 2089
反应条件
1: 1-(tert-butoxycarbonyl)-L-proline; isobutyl chloroformate With 4-methyl-morpholine in dichloromethane T=-25°C; 0.333333 h; Inert atmosphere; 2: diazomethane in diethyl ether; dichloromethane T=-25 - 20°C; Arndt-Eistert synthesis; 16 h; Inert atmosphere;
参考文献
Proteau-Gagne, Arnaud; Nadon, Jean-Franois; Bernard, Sylvain; Guerin, Brigitte; Gendron, Louis; Dory, Yves L.
Tetrahedron Letters, 2011 , vol. 52, # 49 p. 6603 - 6605
反应条件
sodium hydrogencarbonate; triethylamine in tetrahydrofuran; water; toluene
参考文献
Japan Tobacco Inc.
Patent: US5536737 A1, 1996 ;
反应条件
triethylamine in ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US4626545 A1, 1986 ;
反应条件
in tetrahydrofuran; diethyl ether T=-20°C;
参考文献
Niphakis, Micah J.; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 6793 - 6805
反应条件
1: iBuOCOCl, NEt3 View Scheme
参考文献
Harrison, Justin R.; O'Brien, Peter; Porter, David W.; Smith, Neil M.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3623 - 3631
反应条件
potassium hydroxide in methanol; water T=20°C; 1.16667 h;
参考文献
Pinho, Vagner D.; Gutmann, Bernhard; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.; Kappe, C. Oliver
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1555 - 1562
反应条件
1: aq. NaOH / diethyl ether 2: Et3N / tetrahydrofuran / 0.5 h / -20 °C 3: diethyl ether; tetrahydrofuran / -20 °C View Scheme
参考文献
Wallen, Erik A.A.; Christiaans, Johannes A.M.; Saario, Susanna M.; Forsberg, Markus M.; Venaelaeinen, Jarkko I.; Paso, Hanna M.; Maennistoe, Pekka T.; Gynther, Jukka
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2199 - 2206
反应条件
1: aq. NaOH / diethyl ether 2: Et3N / tetrahydrofuran / 0.5 h / -20 °C 3: diethyl ether; tetrahydrofuran / -20 °C View Scheme
参考文献
Wallen, Erik A.A.; Christiaans, Johannes A.M.; Saario, Susanna M.; Forsberg, Markus M.; Venaelaeinen, Jarkko I.; Paso, Hanna M.; Maennistoe, Pekka T.; Gynther, Jukka
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2199 - 2206
反应条件
in diethyl ether T=20°C; Substitution; 16 h;
参考文献
Harrison, Justin R.; O'Brien, Peter; Porter, David W.; Smith, Neil M.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3623 - 3631
