4-氯-2-[2-苯乙烯基]-5,6,7,8-四氢[1]苯并噻吩[2,3-d]嘧啶合成路线 （共 8 条）
反应条件
N,N-dimethyl-formamide; trichlorophosphate 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h;
参考文献
Shishoo; Devani; Ullas; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 825 - 830
反应条件
1: 46 percent / conc. aq. HCl / ethanol / 5 h / Heating 2: 77 percent / POCl3/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h View Scheme
参考文献
Abbas, Safinaz E.; Abdel Gawad, Nagwa M.; George, Riham F.; Akar, Yahya A.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 195 - 204
反应条件
1: 58 percent / HCl(g) / dioxane / Ambient temperature 2: 77 percent / POCl3/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h View Scheme
参考文献
Shishoo; Devani; Ullas; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 825 - 830
反应条件
1: 58 percent / HCl(g) / dioxane / Ambient temperature 2: 77 percent / POCl3/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h View Scheme
参考文献
Shishoo; Devani; Ullas; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 825 - 830
反应条件
1: toluene / 7.5 h / Heating 2: 10percent aq. Na2CO3 / methanol / overnight 3: 77 percent / POCl3/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h View Scheme
参考文献
Shishoo; Devani; Ullas; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 825 - 830
反应条件
1: 10percent aq. Na2CO3 / methanol / overnight 2: 77 percent / POCl3/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h View Scheme
参考文献
Shishoo; Devani; Ullas; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 825 - 830
反应条件
1: 46 percent / conc. aq. HCl / ethanol / 5 h / Heating 2: 77 percent / POCl3/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h View Scheme
参考文献
Shishoo; Devani; Ullas; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 825 - 830
反应条件
1: hydrogenchloride / methanol / 5 h / 20 °C 2: trichlorophosphate View Scheme
参考文献
Abbas, Safinaz E.; Abdel Gawad, Nagwa M.; George, Riham F.; Akar, Yahya A.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 195 - 204
