(1S,2S,3R,6R)-6-[[(2S,3S,4S,5R,6S)-4,5-二羟基-2-(羟基甲基)-6-甲氧基-四氢吡喃-3-基]氨基]-4-(羟基甲基)环己-4-烯-1,2,3-三醇合成路线 （共 5 条）
→
101144-24-5(1S,2S,3R,6R)-6-[[(2S,3S,4S,5R,6S)-4,5-二羟基-2-(羟基甲基)-6-甲氧基-四氢吡喃-3-基]氨基]-4-(羟基甲基)环己-4-烯-1,2,3-三醇
反应条件
acetic acid T=60°C; 2 h;
参考文献
Ogawa; Uchida; Shibata
Carbohydrate Research, 1992 , vol. 223, p. 279 - 286
→
101144-24-5(1S,2S,3R,6R)-6-[[(2S,3S,4S,5R,6S)-4,5-二羟基-2-(羟基甲基)-6-甲氧基-四氢吡喃-3-基]氨基]-4-(羟基甲基)环己-4-烯-1,2,3-三醇
反应条件
1: 51 percent / propan-2-ol / 45 h / 120 °C 2: 100 percent / aq. 70percent AcOH / 2 h / 60 °C View Scheme
参考文献
Ogawa; Uchida; Shibata
Carbohydrate Research, 1992 , vol. 223, p. 279 - 286
→
101144-24-5(1S,2S,3R,6R)-6-[[(2S,3S,4S,5R,6S)-4,5-二羟基-2-(羟基甲基)-6-甲氧基-四氢吡喃-3-基]氨基]-4-(羟基甲基)环己-4-烯-1,2,3-三醇
反应条件
1: 97 percent / H2S, 50percent aq. pyridine / 2 h / Ambient temperature 2: 51 percent / propan-2-ol / 45 h / 120 °C 3: 100 percent / aq. 70percent AcOH / 2 h / 60 °C View Scheme
参考文献
Ogawa; Uchida; Shibata
Carbohydrate Research, 1992 , vol. 223, p. 279 - 286
→
101144-24-5(1S,2S,3R,6R)-6-[[(2S,3S,4S,5R,6S)-4,5-二羟基-2-(羟基甲基)-6-甲氧基-四氢吡喃-3-基]氨基]-4-(羟基甲基)环己-4-烯-1,2,3-三醇
反应条件
1: 51 percent / propan-2-ol / 45 h / 120 °C 2: 100 percent / aq. 70percent AcOH / 2 h / 60 °C View Scheme
参考文献
Ogawa; Uchida; Shibata
Carbohydrate Research, 1992 , vol. 223, p. 279 - 286
→
101144-24-5(1S,2S,3R,6R)-6-[[(2S,3S,4S,5R,6S)-4,5-二羟基-2-(羟基甲基)-6-甲氧基-四氢吡喃-3-基]氨基]-4-(羟基甲基)环己-4-烯-1,2,3-三醇+
反应条件
Yield given. Multistep reaction;
参考文献
Ogawa, Seiichiro; Yasuda, Kuninobu; Takagaki, Tohei; Iwasawa, Yoshikazu; Suami, Tetsuo
Carbohydrate Research, 1985 , vol. 141, p. 329 - 334
