氮杂丁烷-1,3,3-三羧酸 1-叔丁酯 3-乙酯合成路线 (共 2 条)
反应条件
1: With sodium hydroxide; ethanol; water 39 h; 2: With hydrogenchloride; water in ethanol pH=1;
参考文献
WO2008/28937 A1, ;
Page/Page column 99 ;
WO 2008/028937 A1
反应条件
1: azetidine-1,3,3-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester With diphenyl phosphoryl azide; triethylamine in toluene T=80°C; 4 h; 2: tert-butyl alcohol in toluene 4 h;
参考文献
NOVARTIS AG
Patent: WO2009/10488 A1, 2009 ;
Location in patent: Page/Page column 36-37 ;
WO 2009/010488 A1