2-氨基-5-(4-(甲氧基羰基)苯基)-1H-吡咯-3-羧酸乙酯合成路线 （共 6 条）
反应条件
1: ethyl 2-amidinoacetate hydrochloride With sodium in ethanol T=0°C; 0.5 h; 2: ω-bromo-4-methoxycarbonylacetophenone in ethanol T=20°C; 24 h;
参考文献
CURIS, INC.
Patent: WO2008/33745 A2, 2008 ;
Location in patent: Page/Page column 71 ;
WO 2008/033745 A2
反应条件
1: ethyl 2-amidinoacetate hydrochloride With sodium in ethanol T=0°C; 0.5 h; 2: ω-bromo-4-methoxycarbonylacetophenone in ethanol T=20°C; 24 h;
参考文献
CURIS, INC.
Patent: WO2008/33747 A2, 2008 ;
Location in patent: Page/Page column 255 ;
反应条件
1: ethanol With sodium 0.5 h; 2: ethyl 2-amidinoacetate hydrochloride T=20°C; 0.5 h; 3: ω-bromo-4-methoxycarbonylacetophenone T=20°C;
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
Location in patent: Page/Page column 70 ;
反应条件
formic acid in N,N-dimethyl-formamide T=150°C;
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
Location in patent: Page/Page column 70-71 ;
反应条件
formic acid; formamide in N,N-dimethyl-formamide T=150°C; 16 h;
参考文献
CURIS, INC.
Patent: WO2008/33745 A2, 2008 ;
Location in patent: Page/Page column 71 ;
WO 2008/033745 A2
反应条件
1: formic acid / N,N-dimethyl-formamide / 150 °C 2: trichlorophosphate / |Reflux View Scheme
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
Title/Abstract Full Text Show Details
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; SINGH, Umesh
Patent: WO2013/157021 A1, 2013 ;
