4-(4-氧代-4,7-二氢-3H-吡咯并[2,3-d]嘧啶-6-基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
formic acid in N,N-dimethyl-formamide T=150°C;
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
Location in patent: Page/Page column 70-71 ;
反应条件
formic acid; formamide in N,N-dimethyl-formamide T=150°C; 16 h;
参考文献
CURIS, INC.
Patent: WO2008/33745 A2, 2008 ;
Location in patent: Page/Page column 71 ;
WO 2008/033745 A2
反应条件
1.1: sodium / 0.5 h 1.2: 0.5 h / 20 °C 1.3: 20 °C 2.1: formic acid / N,N-dimethyl-formamide / 150 °C View Scheme
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
反应条件
trichlorophosphate Reflux;
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
Location in patent: Page/Page column 70-71 ;
