反应条件
1: 3-(tetrahydro-2H-pyran-4-yl)propanoic acid With thionyl chloride 1 h; Heating / reflux; 2: 1,1-dimethylethylmagnesium chloride With copper(l) chloride in tetrahydrofuran T=0 - 20°C; 3: With water; ammonium chloride in tetrahydrofuran T=0°C;
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2070927 A1, 2009 ;
Location in patent: Page/Page column 28 ;
EP 2070927 A1