5-氰基-2-甲基-6-氧代-1,6-二氢-3-吡啶羧酸合成路线 （共 7 条）
反应条件
potassium hydroxide in ethanol 4 h; Heating;
参考文献
ASTRAZENECA AB
Patent: WO2007/8140 A1, 2007 ;
Location in patent: Page/Page column 173 ;
WO 2007/008140 A1
反应条件
1: 2-cyano-acetamide With sodium ethanolate in ethanol T=20°C; 0.133333 h; Inert atmosphere; 2: 2-Dimethylaminomethylen-acetessigsaeureethylester in ethanol T=20°C; 3: With acetic acid in ethanol
参考文献
ASTRAZENECA AB; BYLUND, Ruth; HOVDAL, Daniel; JOHANSSON, Johan; SELLEN, Mikael; ZETTERBERG, Fredrik
Patent: WO2010/5385 A1, 2010 ;
Location in patent: Page/Page column 77-78; 85-86 ;
WO 2010/005385 A1
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
参考文献
American Hospital Supply Corporation
Patent: US4555517 A1, 1985 ;
反应条件
1: With potassium hydroxide; water in ethanol 12 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
ASTRAZENECA AB
Patent: US2008/176827 A1, 2008 ;
Location in patent: Page/Page column 19 ;
US 20080176827 A1
反应条件
1: 67 percent / NaOEt / ethanol / 24 h / Ambient temperature 2: 98 percent / KOH / aq. ethanol / 4 h / Heating View Scheme
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
反应条件
copper in quinoline 3 h; Heating;
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 16.8333 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: US2008/176827 A1, 2008 ;
Location in patent: Page/Page column 19 ;
US 20080176827 A1
