4-羟基-7-甲氧基-6-硝基喹唑啉合成路线 （共 7 条）
反应条件
sodium T=100°C; 18 h;
参考文献
Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
反应条件
methanol; sodium T=100°C; 20 h;
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2009/76022 A1, 2009 ;
Location in patent: Page/Page column 74 ;
US 20090076022 A1
反应条件
1: methanol With sodium 0.166667 h; Inert atmosphere; 2: 7-fluoro-6-nitroquinazolin-4(3H)-one 3 h; Inert atmosphereReflux;
参考文献
HUTCHISON MEDIPHARMA LIMITED; ZHANG, Weihan; SU, Wei-Guo; YANG, Haibin; CUI, Yumin; REN, Yongxin; YAN, Xiaoqiang
Patent: WO2012/356 A1, 2012 ;
Location in patent: Page/Page column 12 ;
WO 2012/000356 A1
反应条件
1.1: ethanol / Reflux 2.1: nitric acid; sulfuric acid / 72 h / 0 - 100 °C 3.1: sodium / 0.17 h / Inert atmosphere 3.2: 3 h / Inert atmosphere; Reflux View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
反应条件
1: in dimethyl sulfoxide 0.5 h; Cooling with ice; 2: With anhydrous potassium trimethylsilanolate in dimethyl sulfoxide
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
Location in patent: Page/Page column 73 ;
反应条件
1.1: nitric acid; sulfuric acid / 72 h / 0 - 100 °C 2.1: sodium / 0.17 h / Inert atmosphere 2.2: 3 h / Inert atmosphere; Reflux View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; ZHANG, Weihan; SU, Wei-Guo; YANG, Haibin; CUI, Yumin; REN, Yongxin; YAN, Xiaoqiang
Patent: WO2012/356 A1, 2012 ;
WO 2012/000356 A1
反应条件
trichlorophosphate
0.5 h; Heating;
参考文献
Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
