1: 3.4 M REDAL / tetrahydrofuran; toluene / 0.5 h / 85 °C 2: triethylamine / tetrahydrofuran / 90 h 3: pyridine / 6 h / Ambient temperature 4: lithium chloride / dimethylformamide / 0.42 h / 80 °C 5: ammonium formate / 10percent Pd/C / tetrahydrofuran; methanol / 0.33 h / Ambient temperature 6: hydrogen chloride gas / ethyl acetate / 0.67 h 7: 54 percent / EDC / N,N-dimethyl-acetamide / 2 h / Ambient temperature 8: triethylamine / acetonitrile; H2O / 1 h / Ambient temperature View Scheme

Multi-step reaction with 7 steps 1: 3.4 M REDAL / tetrahydrofuran; toluene / 0.5 h / 85 °C2: triethylamine / tetrahydrofuran / 90 h3: pyridine / 6 h / Ambient temperature4: lithium chloride / dimethylformamide / 0.42 h / 80 °C5: ammonium formate / 10percent Pd/C / tetrahydrofuran; methanol / 0.33 h / Ambient temperature6: hydrogen chloride gas / ethyl acetate / 0.67 h7: 58 percent / EDC / N,N-dimethyl-acetamide / 3 h