6-氯-5-(4-氯苯基)-3-吡啶羧酸甲酯合成路线 （共 4 条）
反应条件
sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in water; toluene T=90°C; 2 h;
参考文献
Hebeisen, Paul; Roever, Stephan
Patent: US2008/70931 A1, 2008 ;
Location in patent: Page/Page column 11 ;
US 20080070931 A1
反应条件
1: trichlorophosphate; quinoline / 2 h / 120 °C / |Inert atmosphere 2: dichloromethane / 1.25 h / 70 °C / |Inert atmosphere 3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / toluene; water / 1 h / 90 °C / |Inert atmosphere View Scheme
参考文献
Roever, Stephan; Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Guba, Wolfgang; Hebeisen, Paul; Mohr, Susanne; Nettekoven, Matthias; Obst, Ulrike; Richter, Wolfgang F.; Ullmer, Christoph; Waldmeier, Pius; Wright, Matthew B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9874 - 9896
反应条件
1: acetic acid; bromine / 18.75 h / 45 - 50 °C / |Inert atmosphere 2: trichlorophosphate; quinoline / 2 h / 120 °C / |Inert atmosphere 3: dichloromethane / 1.25 h / 70 °C / |Inert atmosphere 4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / toluene; water / 1 h / 90 °C / |Inert atmosphere View Scheme
参考文献
Roever, Stephan; Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Guba, Wolfgang; Hebeisen, Paul; Mohr, Susanne; Nettekoven, Matthias; Obst, Ulrike; Richter, Wolfgang F.; Ullmer, Christoph; Waldmeier, Pius; Wright, Matthew B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9874 - 9896
反应条件
1: dichloromethane / 1.25 h / 70 °C / |Inert atmosphere 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / toluene; water / 1 h / 90 °C / |Inert atmosphere View Scheme
参考文献
Roever, Stephan; Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Guba, Wolfgang; Hebeisen, Paul; Mohr, Susanne; Nettekoven, Matthias; Obst, Ulrike; Richter, Wolfgang F.; Ullmer, Christoph; Waldmeier, Pius; Wright, Matthew B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9874 - 9896
