2-氧代-1,2-二氢-3-吡啶羧酸甲酯合成路线 （共 12 条）
反应条件
sulfuric acid in toluene T=20°C; 28 h;
参考文献
SHIONOGI and CO., LTD.
Patent: EP1357111 A1, 2003 ;
Location in patent: Page/Page column 59-60 ;
反应条件
sulfuric acid in methanol; water; benzene
参考文献
Abbott Laboratories
Patent: US5250548 A1, 1993 ;
US 5250548 A
反应条件
1.1: hydrogenchloride; water / 1 h / Reflux 2.1: thionyl chloride / dichloromethane / 3 h / 75 °C 2.2: 2 h / 20 °C View Scheme
参考文献
WO2012/102580 A1, ;
WO 2012/102580 A1
参考文献
Monatshefte fuer Chemie, , vol. 27, p. 364
Monatshefte fuer Chemie, , vol. 28, p. 441
参考文献
European Journal of Medicinal Chemistry, , vol. 61, p. 2 - 25
反应条件
1: 66 percent / N-bromosuccinimide / CH2Cl2 / 48 h / Heating 2: 59 percent / POCl3 / dimethylformamide; CH2Cl2 / 28 h / Ambient temperature View Scheme
参考文献
Taylor; Wong
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3618 - 3624
反应条件
1: 90 percent / N-iodosuccinimide / CH2Cl2 / 48 h / Heating 2: 69 percent / POCl3 / 7 h / Heating View Scheme
参考文献
Taylor; Wong
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3618 - 3624
反应条件
N-iodo-succinimide in dichloromethane 48 h; Heating;
参考文献
Winn, Martin; De, Biswanath; Zydowsky, Thomas M.; Altenbach, Robert J.; Basha, Fatima Z.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2676 - 2688
反应条件
N-bromosuccinmide in dichloromethane 48 h; Heating;
参考文献
Taylor; Wong
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3618 - 3624
反应条件
hydrazine hydrate in ethanol 16 h; Reflux;
参考文献
GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon
Patent: WO2010/125102 A1, 2010 ;
Location in patent: Page/Page column 107-108 ;
WO 2010/125102 A1
