2-氧代-1,2-二氢-3-吡啶羧酸甲酯合成路线 （共 12 条）
反应条件
lithium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 72.5 h;
参考文献
Blake, James F.; Boyd, Steven Armen; De Meese, Jason; Fong, Kin Chiu; Gaudino, John J.; Kaplan, Tomas; Marlow, Allison L.; Seo, Jeongbeob; Thomas, Allen A.; Tian, Hongqi; Cohen, Frederick; Young, Wendy B.
Patent: US2007/238726 A1, 2007 ;
Location in patent: Page/Page column 81 ;
US 20070238726 A1
反应条件
1.1: ethyl 2-oxo-cyclohexanecarboxylate; caesium carbonate; copper(I) bromide / dimethyl sulfoxide / 18 h / 60 °C / |Sealed tube
2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 3 h / 20 °C
2.2: pH 2 - 3
View Scheme
参考文献
Suarez, Rosa M.; Chevot, Franciane; Cavagnino, Andrea; Saettel, Nicolas; Radvanyi, Francois; Piguel, Sandrine; Bernard-Pierrot, Isabelle; Stoven, Veronique; Legraverend, Michel
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 2 - 25
