7-Boc-1-氧代-3-苯基-2,7-二氮杂螺[3.5]壬烷合成路线 （共 2 条）
反应条件
1: benzaldehyde With lithium hexamethyldisilazane in tetrahydrofuran T=-30°C; 2: ethyl 1-tert-butyloxycarbonyl-4-piperidinecarboxylate With lithium diisopropyl amide in tetrahydrofuran T=-78 - 0°C; 3 h; 3: With water in tetrahydrofuran T=0°C; Product distribution / selectivity;
参考文献
Aslanian, Robert G.; Chan, Tin-Yau; Harris, Joel M.; McKittrick, Brian A.; Neustadt, Bernard R.; Palani, Anandan; Priestley, Tony; Smith, Elizabeth M.; Stamford, Andrew; Vaccaro, Henry M.; Xiao, Dong
Patent: US2008/76750 A1, 2008 ;
Location in patent: Page/Page column 46; 50 ;
反应条件
1: ethyl 1-tert-butyloxycarbonyl-4-piperidinecarboxylate With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 2: TMS-N=CH-Ph With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C;
参考文献
Xiao, Dong; Palani, Anandan; Aslanian, Robert; McKittrick, Brian A.; McPhail, Andrew T.; Correll, Craig C.; Phelps, P. Tara; Anthes, John C.; Rindgen, Diane
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 783 - 787
