7-氯-6-氟-1,3-苯并噻唑-2-胺合成路线 （共 4 条）
反应条件
bromine in acetic acid 1 h;
参考文献
GLAXO GROUP LIMITED; BERTANI, Barbara; CREMONESI, Susanna; GARZYA, Vincenzo; MICHELI, Fabrizio; RUPCIC, Renata; SABBATINI, Fabio Maria
Patent: WO2011/151361 A1, 2011 ;
Location in patent: Page/Page column 49 ;
WO 2011/151361 A1
反应条件
bromine; acetic acid T=0 - 20°C;
参考文献
Hazra; Nargund; Rashmi; Chandra, J. N. Narendra Sharath; Nandha; Harish
Archiv der Pharmazie, 2012 , vol. 345, # 2 p. 137 - 146
反应条件
bromine; acetic acid
参考文献
Malmstroem, Jonas; Viklund, Jenny; Slivo, Can; Costa, Ana; Maudet, Mickael; Sandelin, Catrin; Hiller, Goesta; Olsson, Lise-Lotte; Aagaard, Anna; Geschwindner, Stefan; Xue, Yafeng; Vasaenge, Mervi
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5919 - 5923
反应条件
1.1: sodium hydroxide / 24 h / Reflux 2.1: sodium hydroxide / 0.5 h / Reflux 2.2: 1.5 h / Reflux View Scheme
参考文献
Armenise, Domenico; Muraglia, Marilena; Florio, Marco Antonio; De Laurentis, Nicolino; Rosato, Antonio; Carrieri, Antonio; Corbo, Filomena; Franchini, Carlo
Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 407 - 416
