3-(4-氰基-苯基)-3-氧代-丙酸甲酯合成路线 (共 3 条)
反应条件
sodium hydride in ethylene glycol dimethyl ether 3 h; Inert atmosphere;
参考文献
Rostovskii, Nikolai V.; Novikov, Mikhail S.; Khlebnikov, Alexander F.; Khlebnikov, Vsevolod A.; Korneev, Sergei M.
Tetrahedron, 2013 , vol. 69, # 21 p. 4292 - 4301
反应条件
NaH in 1,4-dioxane; mineral oil
参考文献
Pfizer Inc.
Patent: US4546113 A1, 1985 ;
反应条件
dichloro(cycloocta-1,5-diene)palladium(II); N,N-dicyclohexylmethylamine; triethylamine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; magnesium chloride; [(t-Bu)3PH]BF4 in 1,4-dioxane T=80°C; 18 h; Inert atmosphereGlovebox;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Skrydstrup, Troels
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9763 - 9766
Angew. Chem., 2013 , vol. 125, # 37 p. 9945 - 9948