phosphorus trichoride in N,N-dimethyl-formamide 2 h; Ambient temperature;

1: 1.) bromine, 2.) 50 percent NaOH 2: 2.) polyphosphoric acid / 1.) 120 deg C, 2 h, 2.) 160 deg C, 1 h 3: 78.7 percent / 15 percent NaOH / 0.75 h / Heating 4: 53.8 percent / KBr, Pb(OAc)4 / H2O; acetic acid / 30 °C 5: toluene / 3 h / Heating 6: 59 percent / PCl3 / dimethylformamide / 2 h / Ambient temperature View Scheme

1: toluene / 3 h / Heating 2: 59 percent / PCl3 / dimethylformamide / 2 h / Ambient temperature View Scheme

1: 2.) polyphosphoric acid / 1.) 120 deg C, 2 h, 2.) 160 deg C, 1 h 2: 78.7 percent / 15 percent NaOH / 0.75 h / Heating 3: 53.8 percent / KBr, Pb(OAc)4 / H2O; acetic acid / 30 °C 4: toluene / 3 h / Heating 5: 59 percent / PCl3 / dimethylformamide / 2 h / Ambient temperature View Scheme

1: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature 2: 2.) polyphosphoric acid / 1.) 120 deg C, 2 h, 2.) 160 deg C, 1 h 3: 78.7 percent / 15 percent NaOH / 0.75 h / Heating 4: 53.8 percent / KBr, Pb(OAc)4 / H2O; acetic acid / 30 °C 5: toluene / 3 h / Heating 6: 59 percent / PCl3 / dimethylformamide / 2 h / Ambient temperature View Scheme

1: 53.8 percent / KBr, Pb(OAc)4 / H2O; acetic acid / 30 °C 2: toluene / 3 h / Heating 3: 59 percent / PCl3 / dimethylformamide / 2 h / Ambient temperature View Scheme

1: toluene / 3 h / Heating 2: 59 percent / PCl3 / dimethylformamide / 2 h / Ambient temperature View Scheme

1: 78.7 percent / 15 percent NaOH / 0.75 h / Heating 2: 53.8 percent / KBr, Pb(OAc)4 / H2O; acetic acid / 30 °C 3: toluene / 3 h / Heating 4: 59 percent / PCl3 / dimethylformamide / 2 h / Ambient temperature View Scheme

in phosphate buffer pH=7.3; Photolysis; Product distribution;