(S)-3-羟基-1-苄基吡咯烷合成路线 （共 49 条）
参考文献
MEDICHEM, S.A.
Patent: WO2009/153649 A1, 2009 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogen; palladium on activated charcoal in methanol 2 h;
参考文献
Horiguchi; Mochida
Bioscience, Biotechnology and Biochemistry, 1995 , vol. 59, # 7 p. 1287 - 1290
反应条件
hydrogen; palladium on activated charcoal in methanol 2 h;
参考文献
Horiguchi; Mochida
Bioscience, Biotechnology and Biochemistry, 1995 , vol. 59, # 7 p. 1287 - 1290
反应条件
1: 63 percent / pyridine / 48 h / 10 °C 2: 1.4 g / ethyl acetate / 2 h / Heating 3: 14.6 g / aq. Na2CO3 / methanol / 4 h 4: pyridine / 48 h / 10 °C 5: ethanol / 20 h / 140 °C View Scheme
参考文献
Cesare, P. Di; Bouzard, D.; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4205 - 4213
反应条件
1: 86 percent / H2 / Pearlmans catalyst / methanol; H2O / 2 h / 2068.59 Torr 2: Et3N / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Castro; Street; Guiblin; Jelley; Russell; Sternfeld; Beer; Stanton; Matassa
Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3497 - 3500
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 12 p. 2504 - 2511
反应条件
1: Et3N 2: 61 percent / dimethylformamide / 48 h / 60 °C View Scheme
参考文献
Fedij, Victor; Lenoir, Edward A.; Suto, Mark J.; Zeller, James R.; Wemple, James
Tetrahedron: Asymmetry, 1994 , vol. 5, # 7 p. 1131 - 1134
反应条件
1: 1 h / 70 - 80 °C 2: 4.91 g / propan-2-ol / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 12 p. 2504 - 2511
反应条件
in dichloromethane; N,N-dimethyl-formamide 15 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 12 p. 2504 - 2511
反应条件
hydrogen; palladium hydroxide - carbon in methanol; water P=2068.59 Torr; 2 h;
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5854268 A1, 1998 ;
