(S)-3-羟基-1-苄基吡咯烷合成路线 （共 49 条）
反应条件
hydrogen; palladium hydroxide - carbon in methanol; water P=2068.59 Torr; 2 h;
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5854268 A1, 1998 ;
反应条件
hydrogen; palladium on activated charcoal in methanol 2 h;
参考文献
Horiguchi; Mochida
Bioscience, Biotechnology and Biochemistry, 1995 , vol. 59, # 7 p. 1287 - 1290
反应条件
1: 84 percent / triethylamine / CH2Cl2 / 1.) 0 deg C, 20 min, 2.) room temperature, 1.5 h 2: 87 percent / tetra-n-butylammonium azide / acetonitrile / 1 h / 65 °C 3: 1.) hydrogen, 2.) pyridine, triethylamine / 1.) methanol, 4 atm, room temperature, 4 h, 2.) room temperature, 16 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1586 - 1590
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1586 - 1590
反应条件
1: Et3N / tetrahydrofuran / 4 h / -10 - 0 °C 2: NaN3 / dimethylformamide / 80 °C 3: LiAlH4 / tetrahydrofuran / 6 h / Heating 4: CH2Cl2 / 20 °C View Scheme
参考文献
Huang; Luedtke; Freeman; Wu; Mach
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1815 - 1826
反应条件
pyridine T=10°C; 48 h;
参考文献
EVOTEC AG; DAVENPORT, Adam James; HALLETT, David James
Patent: WO2010/133544 A1, 2010 ;
Location in patent: Page/Page column 45; 46 ;
WO 2010/133544 A1
反应条件
1: 63 percent / pyridine / 48 h / 10 °C 2: 1.4 g / ethyl acetate / 2 h / Heating 3: 14.6 g / aq. Na2CO3 / methanol / 4 h 4: pyridine / 48 h / 10 °C View Scheme
参考文献
Cesare, P. Di; Bouzard, D.; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4205 - 4213
反应条件
1: 84 percent / triethylamine / CH2Cl2 / 1.) 0 deg C, 20 min, 2.) room temperature, 1.5 h 2: 87 percent / tetra-n-butylammonium azide / acetonitrile / 1 h / 65 °C 3: 1.) hydrogen, 2.) pyridine, triethylamine / 1.) methanol, 4 atm, room temperature, 4 h, 2.) room temperature, 16 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1586 - 1590
反应条件
1: 96.7 percent / Et3N / tetrahydrofuran / 4 h / -10 - 0 °C 2: NaN3 / dimethylformamide / 80 °C 3: LiAlH4 / tetrahydrofuran / 6 h / Heating 4: 77 percent / CH2Cl2 / 20 °C View Scheme
参考文献
Huang; Luedtke; Freeman; Wu; Mach
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1815 - 1826
反应条件
1: With 1,4-diaza-bicyclo[2.2.2]octane in tert-butyl methyl ether T=0 - 20°C; 16.3333 - 26.3333 h; 2: With sodium hydrogencarbonate in tert-butyl methyl ether; water; ethyl acetate T=20°C; 1 h;
参考文献
US2004/254219 A1, ;
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