(S)-3-羟基-1-苄基吡咯烷合成路线 （共 49 条）
反应条件
1: Et3N / tetrahydrofuran / 20 h / 20 °C 2: dimethylsulfoxide / 0.83 h / 120 °C 3: 77 percent / aq. NaOH / methanol / Ambient temperature View Scheme
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 59, # 7 p. 1287 - 1290
反应条件
1: 63 percent / pyridine / 48 h / 10 °C 2: 72 percent / ethanol / 20 h / 140 °C View Scheme
参考文献
Cesare, P. Di; Bouzard, D.; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4205 - 4213
反应条件
1: Et3 / toluene 2: 91 percent / acetonitrile / 6 h / 65 °C View Scheme
参考文献
Fedij, Victor; Lenoir, Edward A.; Suto, Mark J.; Zeller, James R.; Wemple, James
Tetrahedron: Asymmetry, 1994 , vol. 5, # 7 p. 1131 - 1134
反应条件
hydrogen; palladium hydroxide - carbon in methanol; water P=2068.59 Torr; 2 h;
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5854268 A1, 1998 ;
反应条件
1: Et3N 2: 61 percent / dimethylformamide / 48 h / 60 °C 3: conc. HCl/H2O / 4 h / 80 °C View Scheme
参考文献
Gmeiner, Peter; Orecher, Florian; Thomas, Christoph; Weber, Klaus
Tetrahedron Letters, 1995 , vol. 36, # 3 p. 381 - 382
反应条件
1: 63 percent / pyridine / 48 h / 10 °C 2: 1.4 g / ethyl acetate / 2 h / Heating 3: 14.6 g / aq. Na2CO3 / methanol / 4 h 4: pyridine / 48 h / 10 °C 5: ethanol / 20 h / 140 °C View Scheme
参考文献
Cesare, P. Di; Bouzard, D.; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4205 - 4213
反应条件
triethylamine in toluene
T=0 - 20°C; 3.91667 h;
参考文献
ACHILLION PHARMACEUTICALS, INC.
Patent: WO2007/14308 A1, 2007 ;
Location in patent: Page/Page column 70 ;
反应条件
sodium hydroxide in tetrahydrofuran; tert-butyl methyl ether
参考文献
Akzo Nobel N.V.
Patent: US6281243 B1, 2001 ;
Title/Abstract Full Text Show Details
Akzo Nobel N.V.
Patent: EP863136 A1, 1998 ;
反应条件
1: With triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=0 - 20°C; 18 h;
2: With ammonium formate; palladium 10 on activated carbon in methanol
T=20°C; 3 h;
参考文献
Pfizer Inc
Patent: US2006/160786 A1, 2006 ;
Location in patent: Page/Page column 40 ;
US 20060160786 A1
