1-叔丁氧碳基-3-吡咯烷酮合成路线 （共 55 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 2.08333 h; 2: With triethylamine in dichloromethane T=-78 - 20°C; 3 h;
参考文献
Cumbre Inc.
Patent: US2005/277633 A1, 2005 ;
Location in patent: Page/Page column 20 ;
US 20050277633 A1
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C; 48 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/11284 A1, 2007 ;
Location in patent: Page/Page column 28-29 ;
WO 2007/011284 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=760.051 Torr;
参考文献
GRUeNENTHAL GMBH
Patent: WO2005/77924 A1, 2005 ;
Location in patent: Page/Page column 71-72 ;
WO 2005/077924 A1
反应条件
triethylamine in dichloromethane; water; dimethyl sulfoxide; ethyl acetate; benzene
反应条件
water in dimethyl sulfoxide T=120 - 130°C; Krapcho reaction; 4 h;
参考文献
Lee, Ji Hoon; Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Shin, Kye Jung; Kim, Dong Chan; Kong, Jae Yang; Lee, Yeonhee; Lee, Sook Ja; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4399 - 4403
反应条件
ω-transaminase from Alcaligenes denitrificans; pyridoxal 5'-phosphate; 2-oxo-propionic acid in sodium phosphate buffer T=37°C; pH=8; 7 h; kinetic resolutionEnzymatic reaction; enantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 6 p. 807 - 812
反应条件
1: NaOH / H2O; tetrahydrofuran / 20 °C 2: triethylamine; trioxide-trimethylamine complex / dimethylsulfoxide / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 2 p. 1022 - 1033
反应条件
1: NaOEt / ethanol / 3 h / Heating 2: 70 percent / H2O / dimethylsulfoxide / 4 h / 120 - 130 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 24 p. 4399 - 4403
反应条件
1: 79 percent / Et3N / dioxane; H2O / 2 h / Ambient temperature 2: 35 percent / PCC / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 46, # 10 p. 3902 - 3911
