1-叔丁氧碳基-3-吡咯烷酮合成路线 （共 55 条）
反应条件
1: 0.67 h / 105 °C 2: hydrazine / ethanol / 4 h / 85 °C / Sealed tube View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COX, Jason, M.; BIFTU, Tesfaye; CHU, Hong Dong; FENG, Danqing; WEBER, Ann, E.
Patent: WO2011/37793 A1, 2011 ;
参考文献
Fukui, Hideto; Inoguchi, Kiyoshi; Nakano, Jun
Heterocycles, 2002 , vol. 56, # 1-2 p. 257 - 264
反应条件
Leifsonia sp. S749 cells alcohol dehydrogenase; β-NADP+; isopropyl alcohol in phosphate buffer T=25°C; pH=7.0; 24 h;
参考文献
Inoue, Kousuke; Makino, Yoshihide; Itoh, Nobuya
Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2539 - 2549
反应条件
Leifsonia sp. S749 cells alcohol dehydrogenase; β-NADP+; isopropyl alcohol in phosphate buffer T=25°C; pH=7.0; 24 h;
参考文献
Inoue, Kousuke; Makino, Yoshihide; Itoh, Nobuya
Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2539 - 2549
反应条件
1: triphenyl-methyl-phosphonium iodide With sodium hydride in tetrahydrofuran T=5 - 10°C; 1 h; Inert atmosphere; 2: 3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran T=5 - 20°C; 12 h; Inert atmosphere;
参考文献
Asinex Limited; KAZULKIN, Denis Nikolaevich; KOCHUBEY, Valeriy Sergeevich
Patent: EP2719696 A1, 2014 ;
Location in patent: Paragraph 0210; 0211 ;
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexanes T=0°C; 0.0833333 h; 2: 3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran; hexanes T=0 - 20°C; 2.5 h;
参考文献
JANSSEN PHARMACEUTICA NV; BREITENBUCHER, Guy, J.; TICHENOR, Mark, S.; MERIT, Jeffrey, E.; HAWRYLUK, Natalie, A.; CHAMBERS, Alison, L.; KEITH, John, M.
Patent: WO2010/141809 A1, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/141809 A1
反应条件
methylidene triphenyl phosphorane in tetrahydrofuran; toluene T=0 - 20°C;
参考文献
Zhuo, Jincong; Li, Yun-Long; Xu, Meizhong; He, Chunhong; Yao, Wenqing
Patent: US2007/208001 A1, 2007 ;
Location in patent: Page/Page column 34 ;
US 20070208001 A1
反应条件
triethylamine in dichloromethane T=0°C; 3.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/73366 A1, 2006 ;
Location in patent: Page/Page column 185 ;
WO 2006/073366 A1
反应条件
ammonia; ammonium chloride in methanol T=20°C; 6 h; Heating / reflux;
参考文献
Cumbre Inc.
Patent: US2005/277633 A1, 2005 ;
Location in patent: Page/Page column 20 ;
US 20050277633 A1
反应条件
Leifsonia sp. S749 cells alcohol dehydrogenase; β-NADP+; isopropyl alcohol in phosphate buffer T=25°C; pH=7.0; 24 h;
参考文献
Inoue, Kousuke; Makino, Yoshihide; Itoh, Nobuya
Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2539 - 2549
