1: 1,2-dimethoxy-4-chloromethyl-benzene With chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc in tetrahydrofuran T=0 - 25°C; 4.5 h; Inert atmosphere; 2: 1-Iodo-6,7-dimethoxyisoquinoline With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in tetrahydrofuran T=25°C; 1.25 h; Inert atmosphere;